When you get a cut, and your skin turns red around the wound - the color in your skin is the inflammation response directing the arteries around the area of possible infection to rupture and destroy themselves. The response is almost immediate, and it can occur anywhere.
Cancer comes from a virus. The patterns are sometimes passed from generation to generation. The cancer virus expresses itself as a constant attempt to break the code of the human telomere - to attempt to decrypt the means by which our cells can be used to make other cells without nuclei. The telomere breaks a piece of itself of in an attempt to stop it.
When cancer arrives in a particular area, what has happened is that the cells in that area have succumbed to the brute force attack by the virus or by an inherited expression of the virus from within other cells that had the latent pattern and program passed down. The cells either fell by means of codebreak or by environmental triggers that allowed them to express. Often these areas are small.
Hit one or more of these areas with an injury, and the inflammation response will arrive. And when it does, it brings with itchemically induced dilation and increased permeability of blood vessels - its hope is that it will flush bacteria out of the area. But cancer cells use that opportunity - the cells do not get flushed and picked up by the active immune response, because they hold the markers of cells that are native to the body. Instead, it waits.
My theory is that the immune response helps to propagate and complete the viral attack phase of cancer and transform it into a self contained metastasis. This is possible because the inflammation response has to be halted actively - else it will destroy everything. Cancer comes from a set of retrovirus that have discovered a means to propagate at the point of the inflammation response resolvers. They are obscure in origin, and become more prevalent as we age - because they rely on genetic error to express. We are designed to keep them from replicating. And , also - they have a certain window to hit the resolver - after which the resolver fully activates into the area of inflammation and contains its mediation with other factors.
This vector consists of an open window at that mediation and resolution of the inflammation response - and it is timed to transforming growth factor. Once that is released, the virus has a short time to code itself to unlock propagation - giving them a workaround for programmed cell death, and the ability to become established in diverse tissue environments.
Vaccines have been designed to prevent cancer in human beings. This represents a revolutionary step forward in recognizing the nature and origin of cancer. The fusion of chromosone 21 and the relationship to certain forms of leukemia will point the way to an experimental confirmation of this theory.
A complete understanding of the inflammation response holds specific promise for patients suffering from bone cancer, particular cancer of the spine - as the inflammation surrounding can be a source of incredible pain. The genetic study associated with 21-trisomy may yield the markers associated with over expression of ETS2 that can help trigger apoptosis in infected tissue and reactive appropriate deletion response.
Track endothelial progenitor cells from the bone marrow to the blood to the tumour-stroma and then when they're incorporated in tumour vasculature - tell them to die. Or better still, find a way to starve off their telomerase so they're nothing more than tiny little dots that eventually get knocked away.
But if one of those little dots happens to get hit by the blade of a knife, and the inflammation response moves in - my theory says that metastasis can occur, especially if the cancer cells are exposed to appropriate levels of the mediating factors.